As I pulled the dish from the oven, the irresistible scent of Italian spices and melted cheese enveloped my kitchen. This Bubble Up Pizza Casserole is my secret weapon for busy weeknights when time is tight, but a hearty meal is a must. Packed with tender biscuit pieces, ground beef, and a touch of zesty pizza sauce, it’s not only a crowd-pleaser but also customizable to suit every palate, including picky eaters. With its quick prep time and high-protein goodness, you’ll find yourself savoring every layer of this comforting dish. Are you ready to make family dinners a delightful adventure? Let’s dive into this simple yet scrumptious recipe!
Why Is This Casserole So Special?
Ease of Preparation: This Bubble Up Pizza Casserole requires minimal prep time, making it a fantastic choice for busy weeknights.
Flavorful Layers: Experience the delicious melding of gooey cheese, seasoned beef, and fresh veggies for satisfying bites every time.
Customizable: Tailor the ingredients to your family’s preferences—swap turkey for ground beef or try a different sauce to keep things exciting!
Kid-Friendly: With its appealing pizza flavors and fun texture, it’s sure to please even the pickiest eaters at the table.
Meal Prep Friendly: Make-ahead tips allow you to assemble and refrigerate before baking—perfect for those last-minute dinner rushes! Consider pairing it with a light salad or some garlic bread for a complete meal and explore the delightful flavors of Squash Casserole Warm for a side option.
Pizza Casserole with Biscuits and Cheese Ingredients
• Dive into the simplicity of this delicious dish!
For the Casserole
- Lean Ground Beef – Provides a hearty protein base for this Pizza Casserole with Biscuits and Cheese; substitute with turkey for a leaner option.
- Bell Peppers – Adds a pop of color and flavor; feel free to swap with spinach or omit if your family prefers a simpler dish.
- Pizza Sauce – Essential for that classic pizza taste; opt for no-sugar-added varieties for a healthier choice.
- Pillsbury Grands Biscuits – Creates the fluffy layers in the casserole; gluten-free biscuit options are available for those with dietary needs.
- Shredded Mozzarella Cheese – Melts beautifully for a creamy texture; replace with cheddar for a different flavor twist.
- Sliced Turkey Pepperoni – Gives an extra kick of flavor and protein; regular pepperoni or a veggie mix can be used for variety.
Step‑by‑Step Instructions for Pizza Casserole with Biscuits and Cheese
Step 1: Prepare Oven
Preheat your oven to 375°F (190°C), ensuring it reaches the right temperature for baking. While the oven heats up, take a 9×13 inch baking dish and generously grease it with cooking spray or a light coat of olive oil, making sure all surfaces are covered to prevent sticking.
Step 2: Cook Beef
In a large skillet over medium heat, add 1 lb of lean ground beef and allow it to cook for 3-4 minutes. Use a spatula to break the beef into small pieces as it browns, cooking until there’s no pink remaining. Afterward, season with salt and pepper to enhance flavor, ensuring your beef is juicy and well-seasoned for the Pizza Casserole with Biscuits and Cheese.
Step 3: Add Peppers
Stir diced bell peppers into the cooked ground beef, sautéing for an additional 3-5 minutes until the peppers become tender and vibrant in color. This step not only adds nutrition but also brings an appealing aroma to your kitchen. Drain any excess liquid from the mixture, then mix in your favorite pizza sauce, creating a robust blend of flavors.
Step 4: Prep Biscuits
Open the can of Pillsbury Grands Biscuits and cut each biscuit into six pieces using a sharp knife or kitchen scissors. Evenly distribute these biscuit pieces across the bottom of your greased baking dish, creating a fluffy base that will rise beautifully during baking—this is what makes the Pizza Casserole with Biscuits and Cheese so special!
Step 5: Assemble Casserole
Carefully combine the beef and pepper mixture with the biscuit pieces in the baking dish, gently stirring to ensure everything is evenly mixed. This will create delightful layers of flavor and texture. Once combined, sprinkle a generous amount of shredded mozzarella cheese on top, followed by turkey pepperoni slices for an extra flavor boost.
Step 6: Bake
Place the assembled casserole into your preheated oven and bake uncovered for 25-30 minutes. Keep an eye on it—you’re looking for a beautifully golden-brown top and bubbly biscuits. The aroma wafting through your home will be irresistible and signals that the Pizza Casserole with Biscuits and Cheese is almost ready!
Step 7: Cool & Serve
Once baked, remove the casserole from the oven and allow it to cool for about 5-10 minutes. This cooling time helps the cheese set, making it easier to slice. When ready, cut into squares and serve warm, optionally garnishing with fresh basil or oregano for an added touch of flavor and color.
How to Store and Freeze Pizza Casserole with Biscuits and Cheese
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Fridge: Store leftover Pizza Casserole with Biscuits and Cheese in an airtight container for up to 3-4 days. Allow it to cool before sealing to keep the moisture balanced.
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Freezer: To extend its life, freeze portions of the casserole in airtight containers or freezer-safe bags for up to 3 months. Label the bags with the date for easy tracking.
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Reheating: Reheat in the oven at 350°F (175°C) for about 20 minutes, or microwave individual portions for 2-3 minutes on high, checking that it’s heated through before serving.
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Thawing: For frozen servings, transfer them to the fridge overnight to thaw before reheating, ensuring they maintain the best texture and flavor.
What to Serve with Bubble Up Pizza Casserole
This delightful dinner opens up a world of pairing possibilities that transform mealtime into a spectacular family gathering.
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Garlic Bread: A warm, crispy side that provides the perfect texture contrast to the fluffy casserole. The buttery, garlicky aroma is simply irresistible!
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Caesar Salad: Crisp romaine topped with creamy Parmesan dressing complements the hearty casserole, bringing a refreshing crunch to each bite. It’s a classic pairing that never gets old.
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Steamed Broccoli: Bright green and slightly tender, steamed broccoli adds a nutritious note and balances the richness of the casserole. A squeeze of lemon can elevate this simple side even further.
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Italian Antipasto Platter: A colorful assortment of cured meats, olives, and cheeses adds flavor variety while keeping the Italian theme alive. It’s a fun way for everyone to nibble before diving into the main dish!
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Fruit Salad: Fresh, juicy fruits provide a sweet counterbalance to the savory casserole. A mix of berries, melons, and citrus will brighten the plate and palate.
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Sparkling Water with Lemon: A bubbly, refreshing drink that cleanses the palate between bites. It’s a light choice that perfectly complements the robust flavors of the casserole.
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Chocolate Chip Cookies: End the meal on a sweet note with warm, gooey cookies. A perfect dessert that’s sure to please kids and adults alike, making family dinners a cherished occasion.
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Zucchini Noodles: For a lighter option, serve spiralized zucchini sautéed with garlic and olive oil. This will add a lovely freshness alongside your casserole, keeping things vibrant and wholesome.
Feel free to mix and match these ideas to craft your perfect dinner experience!
Make Ahead Options
These delicious Pizza Casserole with Biscuits and Cheese are perfect for busy home cooks looking to save time! You can prepare the casserole up to 24 hours in advance by assembling it and then covering tightly with plastic wrap before refrigerating—this keeps the biscuits from drying out. If you prefer, you can also cook the ground beef and veggies up to 3 days ahead and store them in an airtight container, allowing for even quicker assembly. When you’re ready to enjoy this family favorite, simply remove from the fridge and bake as instructed; this results in a meal that’s just as delicious with minimal effort!
Expert Tips for Pizza Casserole with Biscuits and Cheese
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Prevent Sogginess: Drain any excess liquid from the beef and pepper mixture to avoid a soggy casserole that won’t hold its shape.
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Achieve Crispiness: For extra crispy biscuits, finish baking under the broiler for a couple of minutes, but keep a close eye to prevent burning.
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Make Ahead: Assemble the casserole up to the baking step the night before, refrigerate, and bake it fresh when you’re ready for a quick dinner option.
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Check Doneness: Always check if the biscuits are fully cooked by piercing one with a knife—if it comes out clean, you’re good to go!
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Customize Flavor: Use your favorite toppings or sauces to personalize the Pizza Casserole with Biscuits and Cheese, making it unique for your family’s taste preferences.
Pizza Casserole with Biscuits and Cheese Variations
Feel free to get creative with your pizza casserole by exploring these scrumptious twists and substitutions!
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Vegetarian: Replace ground beef with a mix of sautéed mushrooms, zucchini, and spinach for a delicious plant-based option. This adds incredible depth to the dish while keeping it hearty.
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Spicy Kick: Incorporate sliced jalapeños or a dash of hot sauce into the beef mixture to spice things up. This brings a delightful heat that will awaken your taste buds!
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Cheesy Surprise: Experiment with different cheeses such as pepper jack for a zesty flavor, or go for a melty blend of cheddar and Monterey Jack. Each cheese offers a unique twist to the casserole.
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BBQ Flavor: Use barbecue sauce instead of classic pizza sauce; top with grilled chicken or bacon for an exciting BBQ pizza version. This variant brings bold flavors reminiscent of summer cookouts!
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Gluten-Free: Swap Pillsbury Grands Biscuits for a gluten-free biscuit option. This way, everyone can indulge in this delicious casserole without dietary restrictions.
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Add Toppings: Top the casserole with your favorite pizza toppings like olives, artichokes, or pineapple chunks before baking. This personal touch makes every serving special!
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Italian Herb Twist: Mix in Italian seasoning or fresh herbs like basil and oregano into the ground beef. The aromatic herbs will elevate the flavors, creating an authentic pizza experience.
Don’t forget to try pairing this delightful dish with the comforting and savory Chicken Stuffing Casserole or the delightful Fried Strawberry Cheesecake Sandwiches for a perfect family meal!
Pizza Casserole with Biscuits and Cheese Recipe FAQs
How do I choose the best bell peppers for my casserole?
When selecting bell peppers, look for ones that are firm, glossy, and free of dark spots or wrinkles. Vibrant colors indicate ripeness; red, yellow, and orange peppers will add sweetness to your casserole while green peppers bring a slightly bitter crunch. I often buy them organic to ensure the best flavor and health benefits.
How should I store leftover Pizza Casserole with Biscuits and Cheese?
Store your leftover casserole in an airtight container in the refrigerator for up to 3-4 days. Ensure it has cooled to room temperature before sealing to prevent condensation, which can make the dish soggy. Reheat in the oven or microwave, checking to make sure it’s heated through.
Can I freeze Pizza Casserole with Biscuits and Cheese?
Absolutely! To freeze, allow the casserole to cool completely before cutting it into portions. Then, wrap each piece tightly in plastic wrap and place them in a freezer-safe bag or container. It can be stored for up to 3 months. When you’re ready to enjoy it again, thaw overnight in the refrigerator before reheating in the oven at 350°F until warm.
What if my casserole is too soggy after baking?
If your casserole turns out soggy, this could be due to excess liquid from the beef and peppers. Next time, make sure to drain any added moisture well before mixing. For immediate fixes, you can place it back in the oven uncovered for a few more minutes to help evaporate some moisture. Using a layer of breadcrumbs on top for the last few minutes of baking can also help absorb extra liquid and add a nice crunch.
Is this Pizza Casserole with Biscuits and Cheese suitable for gluten-free diets?
Yes! You can easily make this casserole gluten-free by using gluten-free biscuit options available in stores. Just check the labels to ensure they meet your dietary needs. Additionally, you might want to choose gluten-free pizza sauce, ensuring everyone at the table can enjoy this comforting dish without worry.
Are there any allergen considerations with this recipe?
Keep in mind that this recipe contains common allergens such as dairy (from the cheese) and gluten (if not using gluten-free biscuits). If you have dietary restrictions or are cooking for someone with allergies, consider using dairy alternatives like almond or coconut cheese, and make sure your biscuits are certified gluten-free. Always double-check ingredient labels to ensure safety!

Delicious Pizza Casserole with Biscuits and Cheese for Family Fun
Ingredients
Equipment
Method
- Preheat your oven to 375°F (190°C) and grease a 9x13 inch baking dish.
- In a large skillet, cook 1 lb of lean ground beef over medium heat for 3-4 minutes until no pink remains. Season with salt and pepper.
- Add 1 cup of diced bell peppers, sautéing for 3-5 minutes until tender. Drain excess liquid and mix in 1 cup of pizza sauce.
- Cut each biscuit into six pieces and arrange them in the bottom of the greased baking dish.
- Combine the beef and pepper mixture with the biscuit pieces, then sprinkle with 2 cups of shredded mozzarella cheese and top with turkey pepperoni.
- Bake uncovered for 25-30 minutes until the top is golden-brown and biscuits are bubbly.
- Allow to cool for 5-10 minutes before slicing into squares and serving warm.
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